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RCWIH BioBank Tissue Microarrays

Tissue microarrays (TMAs) represent powerful tools for the identification and validation of molecular targets with clinical significance, and offer researchers many advantages including:

Power to analyze multiple clinical specimens or subjects on a single slide
Improved ability to make direct sample-to-sample comparisons by eliminating experimental variability associated with staining procedures
Reduced costs for antibodies and immunohistochemical reagents
Efficient use of laboratory resources with reduced time required for slide processing
Conservation of precious clinical specimens

RCWIH BioBank TMAs are constructed from our specimen archive which contains more than 1500 paraformaldehyde-fixed, paraffin-embedded (PFPE) tissue blocks, each accompanied by a detailed clinical profile. BioBank TMAs are available in 112 x 1mm core array, or 135 x 1mm core array formats and are accompanied by a detailed TMA map and comprehensive clinical report for all samples. Prepared slides are available from pre-designed BioBank TMAs, or alternatively custom-built TMAs are available upon request.

For additional information regarding BioBank TMAs please contact our office.

Pre-designed RCWIH BioBank TMAs

TMA#1: Intrauterine Growth Restriction (IUGR) and Preeclampsia (PET) Aarray

Features: (view map schematic for TMA1)

(view representative H&E stain for TMA1)

112 x 1mm placental (villous tissue) cores
4 x 1mm beacon cores (prepared from PFPE umbilical cord tissue) for TMA orientation
28 unique subjects represented:
- 8 IUGR
- 8 PET (including 3 cases with HELLP syndrome)
- 6 preterm controls
- 6 term controls

4 replicate placental tissue cores per subject
Accompanied by a comprehensive clinical summary for each subject
- All clinical data reviewed and audited by a Maternal-Fetal Medicine Specialist with the Mount Sinai Hospital Special Pregnancy Program
Accompanied by findings from the pathological evaluation of the complete placenta
- Evaluations are conducted by a Perinatal Pathologist with the Mount Sinai Hospital Department of Pathology and Laboratory Medicine

TMA#2: Gestational Age Profile Array

Features: (view map schematic for TMA2)

(view representative H&E stain for TMA2)

135 x 1mm placental (villous tissue) cores
6 x 1mm beacon cores (prepared from PFPE umbilical cord tissue) for TMA orientation
gestational ages from 4 weeks to 37+ weeks represented

6 replicate placental tissue cores per subject (each gestational age is represented by one unique subject)
Accompanied by a comprehensive clinical summary for each subject
- All clinical data reviewed and audited by a Maternal-Fetal Medicine Specialist with the Mount Sinai Hospital Special Pregnancy Program
Accompanied by findings from the pathological evaluation of the complete placenta
- Evaluations are conducted by a Perinatal Pathologist with the Mount Sinai Hospital Department of Pathology and Laboratory Medicine

RCWIH BioBank TMA#1

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