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BIOBANK

Research Centre for Womenís and Infantsí Health

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Pre-designed RCWIH BioBank TMAs

 
 

 

 

 

Click to make a donation towards the RCWIH BioBank program

 

RCWIH BioBank Tissue Microarrays

Tissue microarrays (TMAs) represent powerful tools for the identification and validation of molecular targets with clinical significance, and offer researchers many advantages including:
  • Power to analyze multiple clinical specimens or subjects on a single slide
  • Improved ability to make direct sample-to-sample comparisons by eliminating experimental variability associated with staining procedures
  • Reduced costs for antibodies and immunohistochemical reagents
  • Efficient use of laboratory resources with reduced time required for slide processing
  • Conservation of precious clinical specimens
 
RCWIH BioBank TMAs are constructed from our specimen archive which contains more than 1500 paraformaldehyde-fixed, paraffin-embedded (PFPE) tissue blocks, each accompanied by a detailed clinical profile. BioBank TMAs are available in 112 x 1mm core array, or 135 x 1mm core array formats and are accompanied by a detailed TMA map and comprehensive clinical report for all samples. Prepared slides are available from pre-designed BioBank TMAs, or alternatively custom-built TMAs are available upon request.
 
For additional information regarding BioBank TMAs please contact our office.
 

 

 


 
 

Pre-designed RCWIH BioBank TMAs

TMA#1: Intrauterine Growth Restriction (IUGR) and Preeclampsia (PET) Aarray

  • 112 x 1mm placental (villous tissue) cores
  • 4 x 1mm beacon cores (prepared from PFPE umbilical cord tissue) for TMA orientation
  • 28 unique subjects represented:
    • 8 IUGR
    • 8 PET (including 3 cases with HELLP syndrome)
    • 6 preterm controls
    • 6 term controls
  • 4 replicate placental tissue cores per subject
  • Accompanied by a comprehensive clinical summary for each subject
    • All clinical data reviewed and audited by a Maternal-Fetal Medicine Specialist with the Mount Sinai Hospital Special Pregnancy Program
  • Accompanied by findings from the pathological evaluation of the complete placenta
    • Evaluations are conducted by a Perinatal Pathologist with the Mount Sinai Hospital Department of Pathology and Laboratory Medicine

TMA#2: Gestational Age Profile Array

  • 135 x 1mm placental (villous tissue) cores
  • 6 x 1mm beacon cores (prepared from PFPE umbilical cord tissue) for TMA orientation
  • gestational ages from 4 weeks to 37+ weeks represented
  • 6 replicate placental tissue cores per subject (each gestational age is represented by one unique subject)
  • Accompanied by a comprehensive clinical summary for each subject
    • All clinical data reviewed and audited by a Maternal-Fetal Medicine Specialist with the Mount Sinai Hospital Special Pregnancy Program
  • Accompanied by findings from the pathological evaluation of the complete placenta
    • Evaluations are conducted by a Perinatal Pathologist with the Mount Sinai Hospital Department of Pathology and Laboratory Medicine
RCWIH BioBank TMA#1
RCWIH BioBank TMA#1
 
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