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BIOBANK

Research Centre for Women’s and Infants’ Health
 

Publications Using Samples From the RCWIH BioBank

 

  1. Chakraborty D, Cui W, Rosario GX, Scott RL, Dhakal P, Renaud SJ, Tachibana M, Rumi MAK, Mason CW, Krieg AJ and Soares MJ. HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia. Proceedings of the National Academy of Sciences USA. 113: E7212-E7221. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27807143

  2. Zhu L, Baczyk D, Lye SJ, Zhang Z. Preeclampsia is associated with low placental transthyretin levels. Taiwan J Obstet Gynecol; 55:385-389. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27343320

  3. Van Mieghem T, Doherty A, Baczyk D, Drewlo S, Baud D, Carvalho J, Kingdom J. Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency. Reprod Sci; 23:1037-1043. 2016; https://www.ncbi.nlm.nih.gov/pubmed/26880769

  4. Roifman M, Choufani S, Turinsky AL, Drewlo S, Keating S, Brudno M, Kingdom J, Weksberg R. Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction. Clin Epigenetics; 8:70. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27330572

  5. Portnoy S, Osmond M, Zhu MY, Seed M, Sled JG, Macgowan CK. Relaxation properties of human umbilical cord blood at 1.5 Tesla. Magn Reson Med. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27059881

  6. Papp E, Balogun K, Banko N, Mohammadi H, Loutfy M, Yudin MH, Shah R, MacGillivray J, Murphy KE, Walmsley SL, Silverman M, Serghides L. Low Prolactin and High 20-alpha-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy. J Infect Dis; 213:1532-1540. 2016; https://www.ncbi.nlm.nih.gov/pubmed/26740274

  7. Mordant P, Nakajima D, Kalaf R, Iskender I, Maahs L, Behrens P, Coutinho R, Iyer RK, Davies JE, Cypel M, Liu M, Waddell TK, et al. Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation. J Heart Lung Transplant; 35:1245-1254. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27444694

  8. Leavey K, Benton SJ, Grynspan D, Kingdom JC, Bainbridge SA, Cox BJ. Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia. Hypertension; 68:137-147. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27160201

  9. Gunatillake T, Yong HE, Dunk CE, Keogh RJ, Borg AJ, Cartwright JE, Whitley GS, Murthi P. Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction. Reproduction; 152:457-465. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27539603

  10. Renaud SJ, Chakraborty D, Mason CW, Rumi MAK, Vivian JL and Soares MJ. OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proceedings of the National Academy of Sciences USA; 112: E6175-E6184. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26504231

  11. Zhang J, Dunk CE, Kwan M, Jones RL, Harris LK, Keating S, Lye SJ. Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy. Cell Mol Immunol. 2015; http://www.ncbi.nlm.nih.gov/pubmed/26277900

  12. Petrovic V, Kojovic D, Cressman A, Piquette-Miller M. Maternal bacterial infections impact expression of drug transporters in human placenta. Int Immunopharmacol; 26:349-356. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25912346

  13. Petropoulos S, Guillemin C, Ergaz Z, Dimov S, Suderman M, Weinstein-Fudim L, Ornoy A, Szyf M. Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling. Endocrinology; 156:2222-2238. 2015; https://www.ncbi.nlm.nih.gov/pubmed/25514087

  14. Papp E, Mohammadi H, Loutfy MR, Yudin MH, Murphy KE, Walmsley SL, Shah R, MacGillivray J, Silverman M, Serghides L. HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction. J Infect Dis; 211:10-18. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25030058

  15. Otto T, Gellhaus A, Luschen N, Scheidler J, Bendix I, Dunk C, Wolf N, Lennartz K, Koninger A, Schmidt M, Kimmig R, Fandrey J, et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia? J Cell Biochem; 116:2924-2937. 2015; http://www.ncbi.nlm.nih.gov/pubmed/26018820

  16. Melland-Smith M, Ermini L, Chauvin S, Craig-Barnes H, Tagliaferro A, Todros T, Post M, Caniggia I. Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia. Autophagy; 11:653-669. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25853898

  17. Melamed N, Choufani S, Wilkins-Haug LE, Koren G, Weksberg R. Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies. Epigenetics; 10:474-483. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25580569

  18. Lye P, Bloise E, Javam M, Gibb W, Lye SJ, Matthews SG. Impact of bacterial and viral challenge on multidrug resistance in first- and third-trimester human placenta. Am J Pathol; 185:1666-1675. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25963552

  19. Lo KC, Yildiz C, Zhu Y, Lambourne MD, Mullen JB, Samplaski MK, Jarvi KA, McKerlie C. Human Fetal Testicular Tissue Xenotransplantation: A Platform to Study the Effect of Gonadotropins on Human Germ Cell Development In Utero. J Urol; 194:585-591. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25656291

  20. Linscheid C, Heitmann E, Singh P, Wickstrom E, Qiu L, Hodes H, Nauser T, Petroff MG. Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women. Placenta; 36:832-838. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26095815

  21. Chauvin S, Yinon Y, Xu J, Ermini L, Sallais J, Tagliaferro A, Todros T, Post M, Caniggia I. Aberrant TGFbeta Signalling Contributes to Dysregulation of Sphingolipid Metabolism in Intrauterine Growth Restriction. J Clin Endocrinol Metab; 100:E986-996. 2015; http://www.ncbi.nlm.nih.gov/pubmed/25942476

  22. Whiteley J, Bielecki R, Li M, Chua S, Ward MR, Yamanaka N, Stewart DJ, Casper RF, Rogers IM. An expanded population of CD34+ cells from frozen banked umbilical cord blood demonstrate tissue repair mechanisms of mesenchymal stromal cells and circulating angiogenic cells in an ischemic hind limb model. Stem Cell Rev; 10:338-350. 2014; https://www.ncbi.nlm.nih.gov/pubmed/24443055

  23. Sharp AN, Heazell AE, Baczyk D, Dunk CE, Lacey HA, Jones CJ, Perkins JE, Kingdom JC, Baker PN, Crocker IP. Preeclampsia is associated with alterations in the p53-pathway in villous trophoblast. PLoS One; 9:e87621. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24498154

  24. Renaud SJ, Kubota K, Rumi MA, Soares MJ. The FOS transcription factor family differentially controls trophoblast migration and invasion. J Biol Chem; 289:5025-5039. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24379408

  25. Quach K, Grover SA, Kenigsberg S, Librach CL. A combination of single nucleotide polymorphisms in the 3'untranslated region of HLA-G is associated with preeclampsia. Hum Immunol; 75:1163-1170. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25454622

  26. Pappas JJ, Petropoulos S, Suderman M, Iqbal M, Moisiadis V, Turecki G, Matthews SG, Szyf M. The multidrug resistance 1 gene Abcb1 in brain and placenta: comparative analysis in human and guinea pig. PLoS One; 9:e111135. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25353162

  27. Levytska K, Drewlo S, Baczyk D, Kingdom J. PPAR- gamma Regulates Trophoblast Differentiation in the BeWo Cell Model. PPAR Res; 2014:637251. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24711815

  28. Lee GT, Price MD, Mejia CA, Galan HL, Arroyo JA. Increased trophoblast expression of NFAT5/TonEBP in pre-eclamptic placentas and hyperosmolar-treated BeWo cells. Eur J Obstet Gynecol Reprod Biol; 183:37-43. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25461350

  29. Kwan M, Hazan A, Zhang J, Jones RL, Harris LK, Whittle W, Keating S, Dunk CE, Lye SJ. Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation. Placenta; 35:1027-1034. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25449030

  30. Javam M, Audette MC, Iqbal M, Bloise E, Gibb W, Matthews SG. Effect of oxygen on multidrug resistance in term human placenta. Placenta; 35:324-330. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24685282

  31. Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein ID, Zandstra PW. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood; 123:650-658. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24243972

  32. Csaszar E, Chen K, Caldwell J, Chan W, Zandstra PW. Real-time monitoring and control of soluble signaling factors enables enhanced progenitor cell outputs from human cord blood stem cell cultures. Biotechnol Bioeng; 111:1258-1264. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24284903 

  33. Bapat P, Kedar R, Lubetsky A, Matlow JN, Aleksa K, Berger H, Koren G. Transfer of dabigatran and dabigatran etexilate mesylate across the dually perfused human placenta. Obstet Gynecol; 123:1256-1261. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24807346

  34. Bahr BL, Price MD, Merrill D, Mejia C, Call L, Bearss D, Arroyo J. Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies. Placenta; 35:883-890. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25260566

  35. Bahr B, Galan HL, Arroyo JA. Decreased expression of phosphorylated placental heat shock protein 27 in human and ovine intrauterine growth restriction (IUGR). Placenta; 35:404-410. 2014; http://www.ncbi.nlm.nih.gov/pubmed/24680694

  36. Audette MC, Challis JR, Jones RL, Sibley CP, Matthews SG. Synthetic glucocorticoid reduces human placental system a transport in women treated with antenatal therapy. J Clin Endocrinol Metab; 99:E2226-2233. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25105735

  37. Renaud SJ, Kubota K, Rumi MAK, Soares SJ. The FOS transcription factor family differentially controls trophoblast migration and invasion. J Biological Chemistry; 289: 5025-5039. 2014; https://www.ncbi.nlm.nih.gov/pubmed/24379408

  38. Amsalem H, Kwan M, Hazan A, Zhang J, Jones RL, Whittle W, Kingdom JC, Croy BA, Lye SJ, Dunk CE. Identification of a novel neutrophil population: proangiogenic granulocytes in second-trimester human decidua. J Immunol; 193:3070-3079. 2014; http://www.ncbi.nlm.nih.gov/pubmed/25135830

  39. Zhang J, Dunk CE, Lye SJ. Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. Hum Reprod; 28:3026-3037. 2013; http://www.ncbi.nlm.nih.gov/pubmed/24001716

  40. Sivasubramaniyam T, Garcia J, Tagliaferro A, Melland-Smith M, Chauvin S, Post M, Todros T, Caniggia I. Where polarity meets fusion: role of Par6 in trophoblast differentiation during placental development and preeclampsia. Endocrinology; 154:1296-1309. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23341197

  41. Schrey S, Kingdom J, Baczyk D, Fitzgerald B, Keating S, Ryan G, Drewlo S. Leptin is differentially expressed and epigenetically regulated across monochorionic twin placenta with discordant fetal growth. Mol Hum Reprod; 19:764-772. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23832168

  42. Lye P, Bloise E, Dunk C, Javam M, Gibb W, Lye SJ, Matthews SG. Effect of oxygen on multidrug resistance in the first trimester human placenta. Placenta; 34:817-823. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23790363

  43. Kalkat M, Garcia J, Ebrahimi J, Melland-Smith M, Todros T, Post M, Caniggia I. Placental autophagy regulation by the BOK-MCL1 rheostat. Autophagy; 9:2140-2153. 2013; http://www.ncbi.nlm.nih.gov/pubmed/24113155

  44. Gallo M, Ho J, Coutinho FJ, Vanner R, Lee L, Head R, Ling EK, Clarke ID, Dirks PB. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res; 73:417-427. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23108137

  45. Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y, Zhao Y, Qiao J, Wang YL, Lye S, Yang BB, Peng C. MicroRNA-376c impairs transforming growth factor-beta and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension; 61:864-872. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23424236

  46. Czikk MJ, Drewlo S, Baczyk D, Adamson SL, Kingdom J. Dual specificity phosphatase 9 (DUSP9) expression is down-regulated in the severe pre-eclamptic placenta. Placenta; 34:174-181. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23276385

  47. Chow T, Whiteley J, Li M, Rogers IM. The transfer of host MHC class I protein protects donor cells from NK cell and macrophage-mediated rejection during hematopoietic stem cell transplantation and engraftment in mice. Stem Cells; 31:2242-2252. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23818226

  48. Baczyk D, Kibschull M, Mellstrom B, Levytska K, Rivas M, Drewlo S, Lye SJ, Naranjo JR, Kingdom JC. DREAM mediated regulation of GCM1 in the human placental trophoblast. PLoS One; 8:e51837. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23300953

  49. Baczyk D, Drewlo S, Kingdom JC. Emerging role of SUMOylation in placental pathology. Placenta; 34:606-612. 2013; http://www.ncbi.nlm.nih.gov/pubmed/23628505

  50. Rolfo A, Garcia J, Todros T, Post M, Caniggia I. The double life of MULE in preeclamptic and IUGR placentae. Cell Death Dis; 3:e305. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22552282

  51. Riddell MR, Winkler-Lowen B, Chakrabarti S, Dunk C, Davidge ST, Guilbert LJ. The characterization of fibrocyte-like cells: a novel fibroblastic cell of the placenta. Placenta; 33:143-150. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22230251

  52. Qiao W, Quon G, Csaszar E, Yu M, Morris Q, Zandstra PW. PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions. PLoS Comput Biol; 8:e1002838. 2012; https://www.ncbi.nlm.nih.gov/pubmed/23284283

  53. Luo L, Ye G, Nadeem L, Fu G, Yang BB, Honarparvar E, Dunk C, Lye S, Peng C. MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal. J Cell Sci; 125:3124-3132. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22454525

  54. Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, Petri M, Porter TF, Sammaritano L, Stephenson MD, Buyon J, Salmon JE. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum; 64:2311-2318. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22275304

  55. Dunk CE, Roggensack AM, Cox B, Perkins JE, Asenius F, Keating S, Weksberg R, Kingdom JC, Adamson SL. A distinct microvascular endothelial gene expression profile in severe IUGR placentas. Placenta; 33:285-293. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22264586

  56. Dunk CE, Gellhaus A, Drewlo S, Baczyk D, Potgens AJ, Winterhager E, Kingdom JC, Lye SJ. The molecular role of connexin 43 in human trophoblast cell fusion. Biol Reprod; 86:115-121. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22238282

  57. Drewlo S, Levytska K, Kingdom J. Revisiting the housekeeping genes of human placental development and insufficiency syndromes. Placenta; 33:952-954. 2012; https://www.ncbi.nlm.nih.gov/pubmed/23026742

  58. Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell; 10:218-229. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22305571

  59. Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL. Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice. Hypertension; 59:732-739. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22275534

  60. Anger GJ, Cressman AM, Piquette-Miller M. Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes. PLoS One; 7:e35027. 2012; http://www.ncbi.nlm.nih.gov/pubmed/22558111

  61. Yeganegi M, Leung CG, Martins A, Kim SO, Reid G, Challis JR, Bocking AD. Lactobacillus rhamnosus GR-1 stimulates colony-stimulating factor 3 (granulocyte) (CSF3) output in placental trophoblast cells in a fetal sex-dependent manner. Biol Reprod; 84:18-25. 2011; http://www.ncbi.nlm.nih.gov/pubmed/20811016

  62. Sobel ML, Kingdom J, Drewlo S. Angiogenic response of placental villi to heparin. Obstet Gynecol; 117:1375-1383. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21606748

  63. Salmon JE, Heuser C, Triebwasser M, Liszewski MK, Kavanagh D, Roumenina L, Branch DW, Goodship T, Fremeaux-Bacchi V, Atkinson JP. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med; 8:e1001013. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21445332

  64. Rajendram R, Ferreira JC, Grafodatskaya D, Choufani S, Chiang T, Pu S, Butcher DT, Wodak SJ, Weksberg R. Assessment of methylation level prediction accuracy in methyl-DNA immunoprecipitation (MeDIP-CGI) and sodium bisulfite (BIS-Me) based microarray platforms. Epigenetics; 6:410-415. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21343703

  65. Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, Lye S, Peng C. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol; 178:1177-1189. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21356369

  66. Kingdom JC, Walker M, Proctor LK, Keating S, Shah PS, McLeod A, Keunen J, Windrim RC, Dodd JM. Unfractionated heparin for second trimester placental insufficiency: a pilot randomized trial. J Thromb Haemost; 9:1483-1492. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21689371

  67. Grigoriu A, Ferreira JC, Choufani S, Baczyk D, Kingdom J, Weksberg R. Cell specific patterns of methylation in the human placenta. Epigenetics; 6:368-379. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21131778

  68. Ferreira JC, Choufani S, Grafodatskaya D, Butcher DT, Zhao C, Chitayat D, Shuman C, Kingdom J, Keating S, Weksberg R. WNT2 promoter methylation in human placenta is associated with low birthweight percentile in the neonate. Epigenetics; 6:440-449. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21474991

  69. Drewlo S, Levytska K, Sobel M, Baczyk D, Lye SJ, Kingdom JC. Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling. J Thromb Haemost; 9:2486-2497. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21981655

  70. Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J. Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi. Hum Reprod; 26:1025-1034. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21406447

  71. Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, et al. Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Mol Cell Proteomics; 10:M111 012526. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21986993

  72. Choufani S, Shapiro JS, Susiarjo M, Butcher DT, Grafodatskaya D, Lou Y, Ferreira JC, Pinto D, Scherer SW, Shaffer LG, Coullin P, Caniggia I, et al. A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes. Genome Res; 21:465-476. 2011; http://www.ncbi.nlm.nih.gov/pubmed/21324877

  73. Wright JK, Dunk CE, Amsalem H, Maxwell C, Keating S, Lye SJ. HER1 signaling mediates extravillous trophoblast differentiation in humans. Biol Reprod; 83:1036-1045. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20739666

  74. Wong CJ, Casper RF, Rogers IM. Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state. Exp Cell Res; 316:927-939. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20096686

  75. Wolf N, Yang W, Dunk CE, Gashaw I, Lye SJ, Ring T, Schmidt M, Winterhager E, Gellhaus A. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology; 151:2835-2845. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20237132

  76. van Dijk M, van Bezu J, van Abel D, Dunk C, Blankenstein MA, Oudejans CB, Lye SJ. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol Genet; 19:2658-2667. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20400461

  77. van Dijk M, Drewlo S, Oudejans CB. Differential methylation of STOX1 in human placenta. Epigenetics; 5:736-742. 2010; https://www.ncbi.nlm.nih.gov/pubmed/20716964

  78. Rolfo A, Many A, Racano A, Tal R, Tagliaferro A, Ietta F, Wang J, Post M, Caniggia I. Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PLoS One; 5:e13288. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20967267

  79. Ray JE, Garcia J, Jurisicova A, Caniggia I. Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia. Cell Death Differ; 17:846-859. 2010; http://www.ncbi.nlm.nih.gov/pubmed/19942931

  80. Pollex EK, Feig DS, Lubetsky A, Yip PM, Koren G. Insulin glargine safety in pregnancy: a transplacental transfer study. Diabetes Care; 33:29-33. 2010; http://www.ncbi.nlm.nih.gov/pubmed/19808914

  81. Plosch T, Gellhaus A, van Straten EM, Wolf N, Huijkman NC, Schmidt M, Dunk CE, Kuipers F, Winterhager E. The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia? Placenta; 31:910-918. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20709391

  82. Li W, Li H, Bocking AD, Challis JR. Tumor necrosis factor stimulates matrix metalloproteinase 9 secretion from cultured human chorionic trophoblast cells through TNF receptor 1 signaling to IKBKB-NFKB and MAPK1/3 pathway. Biol Reprod; 83:481-487. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20463356

  83. Kirouac DC, Ito C, Csaszar E, Roch A, Yu M, Sykes EA, Bader GD, Zandstra PW. Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol; 6:417. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20924352

  84. Ito CY, Kirouac DC, Madlambayan GJ, Yu M, Rogers I, Zandstra PW. The AC133+CD38-, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures. Blood; 115:257-260. 2010; http://www.ncbi.nlm.nih.gov/pubmed/19897585

  85. Imperatore A, Rolfo A, Petraglia F, Challis JR, Caniggia I. Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3. Reprod Sci; 17:833-843. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20616367

  86. Hazan AD, Smith SD, Jones RL, Whittle W, Lye SJ, Dunk CE. Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro. Am J Pathol; 177:1017-1030. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20558572

  87. Audette MC, Greenwood SL, Sibley CP, Jones CJ, Challis JR, Matthews SG, Jones RL. Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants. Placenta; 31:97-105. 2010; http://www.ncbi.nlm.nih.gov/pubmed/20045184

  88. Yeganegi M, Watson CS, Martins A, Kim SO, Reid G, Challis JR, Bocking AD. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. Am J Obstet Gynecol; 200:532 e531-538. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19285652

  89. Yamanaka N, Wong CJ, Gertsenstein M, Casper RF, Nagy A, Rogers IM. Bone marrow transplantation results in human donor blood cells acquiring and displaying mouse recipient class I MHC and CD45 antigens on their surface. PLoS One; 4:e8489. 2009; http://www.ncbi.nlm.nih.gov/pubmed/20046883

  90. Widdows K, Kingdom JC, Ansari T. Double immuno-labelling of proliferating villous cytotrophoblasts in thick paraffin sections: integrating immuno-histochemistry and stereology in the human placenta. Placenta; 30:735-738. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19524296

  91. Kirouac DC, Madlambayan GJ, Yu M, Sykes EA, Ito C, Zandstra PW. Cell-cell interaction networks regulate blood stem and progenitor cell fate. Mol Syst Biol; 5:293. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19638974

  92. Cox B, Kotlyar M, Evangelou AI, Ignatchenko V, Ignatchenko A, Whiteley K, Jurisica I, Adamson SL, Rossant J, Kislinger T. Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology. Mol Syst Biol; 5:279. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19536202

  93. Chua SJ, Bielecki R, Wong CJ, Yamanaka N, Rogers IM, Casper RF. Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture. Biochem Biophys Res Commun; 379:217-221. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19101517

  94. Cavanagh PC, Dunk C, Pampillo M, Szereszewski JM, Taylor JE, Kahiri C, Han V, Lye S, Bhattacharya M, Babwah AV. Gonadotropin-releasing hormone-regulated chemokine expression in human placentation. Am J Physiol Cell Physiol; 297:C17-27. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19369450

  95. Burgos-Ramos E, Puebla-Jimenez L, Arilla-Ferreiro E. Minocycline prevents Abeta(25-35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex. Life Sci; 84:205-210. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19101571

  96. Baczyk D, Drewlo S, Proctor L, Dunk C, Lye S, Kingdom J. Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death Differ; 16:719-727. 2009; http://www.ncbi.nlm.nih.gov/pubmed/19219068

  97. Rogers IM, Yamanaka N, Casper RF. A simplified procedure for hematopoietic stem cell amplification using a serum-free, feeder cell-free culture system. Biol Blood Marrow Transplant; 14:927-937. 2008; http://www.ncbi.nlm.nih.gov/pubmed/18640577

  98. Pollex E, Lubetsky A, Koren G. The role of placental breast cancer resistance protein in the efflux of glyburide across the human placenta. Placenta; 29:743-747. 2008; http://www.ncbi.nlm.nih.gov/pubmed/18558430

  99. Nevo O, Many A, Xu J, Kingdom J, Piccoli E, Zamudio S, Post M, Bocking A, Todros T, Caniggia I. Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction. J Clin Endocrinol Metab; 93:285-292. 2008; http://www.ncbi.nlm.nih.gov/pubmed/17956955

  100. Guo L, Choufani S, Ferreira J, Smith A, Chitayat D, Shuman C, Uxa R, Keating S, Kingdom J, Weksberg R. Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae. Dev Biol; 320:79-91. 2008; http://www.ncbi.nlm.nih.gov/pubmed/18550048

  101. Gedeon C, Anger G, Piquette-Miller M, Koren G. Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta. Placenta; 29:39-43. 2008; http://www.ncbi.nlm.nih.gov/pubmed/17923155

  102. Gedeon C, Anger G, Lubetsky A, Miller MP, Koren G. Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta. J Obstet Gynaecol; 28:485-489. 2008; http://www.ncbi.nlm.nih.gov/pubmed/18850420

  103. Soleymanlou N, Jurisicova A, Wu Y, Chijiiwa M, Ray JE, Detmar J, Todros T, Zamudio S, Post M, Caniggia I. Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia. Am J Pathol; 171:496-506. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17600131

  104. Rogers I, Yamanaka N, Bielecki R, Wong CJ, Chua S, Yuen S, Casper RF. Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation. Exp Cell Res; 313:1839-1852. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17433293

  105. Gellhaus A, Schmidt M, Dunk C, Lye SJ, Winterhager E. The circulating proangiogenic factors CYR61 (CCN1) and NOV (CCN3) are significantly decreased in placentae and sera of preeclamptic patients. Reprod Sci; 14:46-52. 2007; http://www.ncbi.nlm.nih.gov/pubmed/18089610

  106. Madlambayan GJ, Rogers I, Purpura KA, Ito C, Yu M, Kirouac D, Casper RF, Zandstra PW. Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess. Biol Blood Marrow Transplant; 12:1020-1030. 2006; http://www.ncbi.nlm.nih.gov/pubmed/17084368

  107. Gellhaus A, Schmidt M, Dunk C, Lye SJ, Kimmig R, Winterhager E. Decreased expression of the angiogenic regulators CYR61 (CCN1) and NOV (CCN3) in human placenta is associated with pre-eclampsia. Mol Hum Reprod; 12:389-399. 2006; http://www.ncbi.nlm.nih.gov/pubmed/16675545

 


 
 

 

  
  
    
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